Tumor-Infiltrating Lymphocytes in Melanoma
نویسندگان
چکیده
منابع مشابه
The antigen specific composition of melanoma tumor infiltrating lymphocytes?
Large numbers of tumor associated antigens has been characterized, but only a minor fraction of these are recognized by tumor infiltrating lymphocytes of melanoma, although these have shown the ability to recognize tumor and provide tumor regression upon adoptive transfer. Thus the peptide recognition of the majority of the CD8 tumor infiltrating lymphocytes remains to be identified.
متن کاملExpansion and Characterization of Human Melanoma Tumor-Infiltrating Lymphocytes (TILs)
BACKGROUND Various immunotherapeutic strategies for cancer are aimed at augmenting the T cell response against tumor cells. Adoptive cell therapy (ACT), where T cells are manipulated ex vivo and subsequently re-infused in an autologous manner, has been performed using T cells from various sources. Some of the highest clinical response rates for metastatic melanoma have been reported in trials u...
متن کاملStudies of tumor-infiltrating lymphocytes from a human choroidal melanoma.
Cell suspensions prepared enzymatically from an ocular choroidal melanoma were cultured in vitro in an effort to generate (1) melanoma tumor cell lines and (2) tumor-infiltrating lymphocytes cytotoxic for ocular melanoma cells. Even though histologic study of the tumor did not show "significant" infiltrating bone marrow-derived cells, lymphocytes were generated readily in cultures to which inte...
متن کاملTumor Infiltrating Lymphocytes
9 Abstract 10 11 Tumor infiltrating lymphocytes (TILs) have been recognized in various 12 cancers and may reflect a host immune response to malignant cells. TILs 13 are a heterogeneous population of various types of mononuclear cells, 14 including CD8 or CD4 + T cells and their subsets, B cells, myeloid 15 derived suppressor cells (MDSC), macrophages, and other cells. Immuno16 suppressive facto...
متن کاملTumor-infiltrating lymphocytes in breast cancer
We have prospectively validated in an independent clinical cohort the finding that elevated amounts of tumor-infiltrating lymphocytes in breast carcinoma tissues predict the response of patients to neoadjuvant chemotherapy. These results suggest that a robust tumor infiltration by T and B cells is a promising biomarker to define patients who might benefit from neoadjuvant chemotherapy.
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ژورنال
عنوان ژورنال: Current Oncology Reports
سال: 2012
ISSN: 1523-3790,1534-6269
DOI: 10.1007/s11912-012-0257-5